Belfast International Airport has confirmed that Ryanair has informed them that it will withdraw its operations from there at the end of October.
Seasonal routes offered by the airline from Belfast City Airport are also due to cease at the end of the summer.
This means that from the Autumn, Ryanair looks set to have no services running to or from Northern Ireland.
“It is disappointing that Ryanair has now decided to withdraw operations from the entire Northern Ireland market at the end of October, having variously had a presence in all three local airports in recent years,” a spokesman for Belfast International Airport said.
“It has been a difficult period for aviation and a time when consumers need some stability and faith in the Northern Ireland air transport network.”
Ryanair has not made an announcement as of yet.
People in both the North and the Republic have frequently used Ryanair’s routes from Belfast when traveling abroad.