Ireland have lost their opening fixture of the Guinness Six Nations 2021.
Wales overcame a damaged Ireland, who lost Peter O’Mahony early to a deserving red card.
Ireland showed promise following O’Mahonys departure, with Sexton, Beirne, Henshaw and Lowe playing exceptional.
This loss makes a difficult climb for the boys in green with five games remaining.
Ireland will next host France next Sunday in the Aviva stadium.